Zinc Oxide Versus Petrolatum Following Skin Surgery
Patients undergoing routine surgery in the Department of Dermatology for any indication on non-scalp skin and closed in linear fashion with scar greater than or equal to 4.5cm in length will be invited to participate in this split scar, head to head study comparing zinc oxide and petrolatum. Patients will apply respective ointments to each half of scar daily for one month and maintain a log of these activities. They will be seen at 1 week, 4 weeks, 8 weeks, and 6 months post-operatively for photographic scar assessment and to complete the patient portion of the Patient and Observer Scar Assessment Scale (POSAS), a quantitative objective assessment of scar appearance. Trained observers (board-certified dermatologists) will score the observer portion of the scale. POSAS outcomes, post-operative infections, linear density of epidermal seal will be assessed at the 1 week, 4 weeks, 8 weeks, and 6 months post-operative periods and compared between the two groups. Participants will have parking validated for all visits and upon completion of all portions of the study will receive a standardized skin care gift bag containing samples for hypoallergenic skin care products (washes, moisturizers, etc.).
Conditions:
🦠 Surgical Incision 🦠 Surgery--Complications 🦠 Surgical Wound 🦠 Surgical Site Infection 🦠 Scar 🦠 Hypertrophic Scar
🗓️ Study Start (Actual) 1 September 2021
🗓️ Primary Completion (Estimated) 30 September 2024
✅ Study Completion (Estimated) 30 September 2024
👥 Enrollment (Estimated) 30
🔬 Study Type INTERVENTIONAL
📊 Phase EARLY_PHASE1
Locations:
📍 Pittsburgh, Pennsylvania, United States

📋 Eligibility Criteria

Description

    Inclusion Criteria:

    • 1. ≥ 18 years of age
    • 2. Linear closure, non-scalp site
    • 3. ≥ 4.5 cm in length (final incision/closure length)
    • 4. End to end symmetry (surgical site is not grossly asymmetric from end to end)
    • 5. Grossly uninfected site

    Exclusion Criteria:

    • 1. ≤ 18 years
    • 2. Visibly asymmetric linear scar
    • 3. Grossly infected surgical site
    • 4. History of allergy to topical zinc oxide
Ages Eligible for Study: 18 Years to N/A (ADULT, OLDER_ADULT)
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers: Yes

🗓️ Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

  • First Submitted 7 May 2018
  • First Submitted that Met QC Criteria 16 June 2018
  • First Posted 19 June 2018

Study Record Updates

  • Last Update Submitted that Met QC Criteria 24 September 2023
  • Last Update Posted 26 September 2023
  • Last Verified September 2023