Description
Inclusion Criteria:
- * 18-55
- * verbal agreement to maintain dose of prescribed psychotropic medication (if any) and/or psychotherapy (if any) constant throughout the study, provided they are stable on it for the past 4 weeks (except exclusion medication and except if there is a medical emergency requiring changes in medication).
- * DMQ Impairment score \>= 14
Exclusion Criteria:
- * current or past history of mania or psychosis; current hypomania
- * verbal IQ\< 90 as per the NART
- * not medically cleared for TMS or fMRI (such as taking medications known to reduce the seizure threshold such as Lithium, Clozaril, stimulants including the ADHD medications (e.g. Ritalin, Adderall), Wellbutrin/Buproprion, Provigil (Modafinil), Aminophylline, and Theophylline)
- * DMQ Impairment score \< 14
- * younger than 18 and older than 55
- * pregnant
- * high risk for suicide (defined as having attempted suicide in past 6 months; suicide attempt within the past 10 years with current ideation with plan or preferred method available)
- * moderate/severe current alcohol or substance use disorder, or past severe alcohol use disorder
- * unable to read, blind, or deaf, or unwilling to give consent
- * cannot come to Duke for the in-person study visits
- * current uncontrolled anorexia or other condition requiring hospitalization
- * conditions associated with increased intracranial pressure, space occupying brain lesion, transient ischemic attack, cerebral aneurysm, dementia, Parkinson's or Huntington's disease, multiple sclerosis
- * use of investigational drug or devices within 4 weeks of screening
- * started/changed psychotropic medications or started psychotherapy in the prior 4 weeks, or plans to change medication or stop psychotherapy during the study
Ages Eligible for Study:
18 Years to 55 Years (ADULT)
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers:
No