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Transpulmonary Pressure Guided Mechanical Ventilation Weaning in Obesity
This study will look at whether accounting for the amount of pressure generated by the chest wall and abdomen in a obese patient, using a measurement called transpulmonary pressure, can help shorten the amount of time patients spend on the ventilator. By decreasing the amount of time patients spend on the ventilator, they are less likely to develop complications such as infections, weakness or more procedures.
Conditions:
🦠 Respiratory Failure 🦠 Obesity
🗓️ Study Start (Actual) 11 April 2022
🗓️ Primary Completion (Estimated) 30 March 2025
✅ Study Completion (Estimated) 30 April 2025
👥 Enrollment (Estimated) 128
🔬 Study Type INTERVENTIONAL
📊 Phase NA
Locations:
📍 Jackson, Mississippi, United States

📋 Eligibility Criteria

Description

    Inclusion Criteria:

    • * on invasive mechanical ventilation for respiratory failure for \< 48 hours
    • * obese class II or higher (BMI greater than or equal to 35.0 kg/m2)

    Exclusion Criteria:

    • * contraindications to esophageal balloon catheter placement including esophageal, nasofacial, gastrointestinal abnormalities and platelets \<10,000/microliter
    • * known pleural disease such as persistent pneumothorax, pleural effusion, or pleurodesis
    • * neuromuscular disease
    • * requires chronic mechanical ventilation prior to enrollment
    • * severe neurologic injury
    • * known difficult airway
    • * life expectance is less than 48 hours
Ages Eligible for Study: 18 Years to N/A (ADULT, OLDER_ADULT)
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers: No

🗓️ Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

  • First Submitted 2 September 2022
  • First Submitted that Met QC Criteria 2 September 2022
  • First Posted 7 September 2022

Study Record Updates

  • Last Update Submitted that Met QC Criteria 13 May 2024
  • Last Update Posted 16 May 2024
  • Last Verified May 2024
I'm interested ...!!