TRANSCRIBE (Transcriptomic Analysis of Left Ventricular Gene Expression)

RECRUITING

I'm interested ...!!

Hypothesis: The investigators hypothesize that genetic variants will alter gene expression in response to ischemia during cardiopulmonary bypass. To test this, the investigators will be taking small pieces of heart tissue from patients undergoing heart surgery before and after this period of ischemia. This will be compared to blood gene expression in blood cells and analyzed with the patients' genetic profile. This might allow us to assess the amount of inflammation that occurs when patients are on the heart-lung machine as well as examine the effects genes have on this critical time period.

Conditions:

🦠 Cardiovascular Diseases

🗓️ Study Start (Actual) March 2009

🗓️ Primary Completion (Estimated) December 2024

✅ Study Completion (Estimated) December 2024

👥 Enrollment (Estimated) 350

🔬 Study Type OBSERVATIONAL

📊 Phase N/A

Locations:

📍 Boston, Massachusetts, United States

📋 Eligibility Criteria

Description

Inclusion Criteria:

* Aged greater than 20 years
* Undergoing aortic valve surgery with or without CABG surgery
* Receive and apical vent as part of the surgery

Exclusion Criteria:

* Will not receive an apical left ventricular vent

Ages Eligible for Study: 20 Years to N/A (ADULT, OLDER_ADULT)

Sexes Eligible for Study: ALL

Accepts Healthy Volunteers: No

🗓️ Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

First Submitted 24 September 2009
First Submitted that Met QC Criteria 25 September 2009
First Posted 28 September 2009

Study Record Updates

Last Update Submitted that Met QC Criteria 6 February 2023
Last Update Posted 8 February 2023
Last Verified February 2023