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Thromboxane Function in Women With Endometriosis
The goal of this clinical trial is to compare neurovascular regulation in women with endometriosis and healthy women. The main questions it aims to answer are: * Do women with endometriosis have greater blood pressure and pain responses to a stimulus than healthy women? * Do women with endometriosis have greater platelet activity than healthy women? Participants will take aspirin and/or placebo and will: * perform hand grip exercise and cold pressor tests * undergo iontophoresis and blood draw Researchers will compare women with and without endometriosis to see if there is a difference in neurovascular regulation.
Conditions:
🦠 Endometriosis
🗓️ Study Start (Actual) 1 January 2024
🗓️ Primary Completion (Estimated) 1 August 2026
✅ Study Completion (Estimated) 1 August 2027
👥 Enrollment (Estimated) 96
🔬 Study Type INTERVENTIONAL
📊 Phase PHASE4
Locations:
📍 University Park, Pennsylvania, United States

📋 Eligibility Criteria

Description

    Inclusion Criteria:

    • * Born with a uterus
    • * 18-45 years old
    • * With and without endometriosis

    Exclusion Criteria:

    • * Currently pregnant or breastfeeding
    • * Diagnosed cardiovascular disease
    • * BMI over 35
    • * Nicotine use (e.g., smoking, chewing tobacco, vaping, etc.)
    • * Currently using hormone replacement therapy (or have used within previous 6 months)
    • * Known skin allergies or current rash, skin disease, disorders of pigmentation
    • * Diabetes
    • * Renal disease, renal artery stenosis, renal impairment
    • * Liver disease
    • * Stage II Hypertension (blood pressure \>140/\>90 mmHg)
    • * Hypotension (blood pressure \< 90/60 mmHg)
    • * Raynaud's syndrome
    • * Any current medications which could conceivably alter cardiovascular responses (e.g. antihypertension medication, diuretic, digoxin)
    • * Allergy or hypersensitivity to investigational agents
    • * Immunosuppressed/immunocompromised
Ages Eligible for Study: 18 Years to 45 Years (ADULT)
Sexes Eligible for Study: FEMALE
Accepts Healthy Volunteers: Yes

🗓️ Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

  • First Submitted 30 June 2023
  • First Submitted that Met QC Criteria 18 July 2023
  • First Posted 27 July 2023

Study Record Updates

  • Last Update Submitted that Met QC Criteria 5 February 2024
  • Last Update Posted 6 February 2024
  • Last Verified February 2024
I'm interested ...!!