The Validity of the Quick Renal MRI in Pediatric Kidney Disease
The investigators propose a new imaging method for children born with congenital anomalies of the urinary tract that is a rapid, injection-, sedation-, and radiation-free alternative: the quick renal MRI. This proposal hypothesizes that the quick renal MRI has high validity compared to current radiologic standard for renal infection and scarring, the 99mTechnetium-dimercaptosuccinic acid (99mTc- DMSA) renal scan in the detection of acute renal infections and scars. If the quick renal MRI is accurate, it could potentially replace the DMSA scan for those specific questions and ease the burden of testing for children with chronic renal disease. Findings from these studies will provide preliminary data and rationale for a multi-centered study to further test this new technology. Participants will be 0-21 years of age and can expect to be on study for from 1 week (if enrolled in Aim 1) to 6 months (if enrolled in Aim 2).
Conditions:
🦠 Pyelonephritis 🦠 Pyelonephritis Acute 🦠 Renal Sclerosis
🗓️ Study Start (Actual) 7 May 2019
🗓️ Primary Completion (Estimated) January 2025
✅ Study Completion (Estimated) January 2025
👥 Enrollment (Estimated) 100
🔬 Study Type INTERVENTIONAL
📊 Phase NA
Locations:
📍 Madison, Wisconsin, United States

📋 Eligibility Criteria

Description

    Inclusion Criteria:

    • * Aim 1:
    • * Patient is admitted to American Family Children's Hospital for a febrile UTI, suspected pyelonephritis, or diagnosed pyelonephritis
    • * Undergoing clinical DMSA scan
    • * Aim 2:
    • * Undergoing DMSA scans as a part of their routine clinical care
    • * History of more than one UTI in the past year

    Exclusion Criteria:

    • * Aim 1:
    • * No evidence of pyuria on their urine analysis
    • * Negative urine culture
    • * Not comfortable with having a Quick MRI performed
    • * Both aims:
    • * Contraindications to MRI
Ages Eligible for Study: 0 Years to 21 Years (CHILD, ADULT)
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers: No

🗓️ Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

  • First Submitted 20 May 2019
  • First Submitted that Met QC Criteria 20 May 2019
  • First Posted 22 May 2019

Study Record Updates

  • Last Update Submitted that Met QC Criteria 2 April 2024
  • Last Update Posted 3 April 2024
  • Last Verified April 2024