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The Effects of an Obesogenic Lifestyle in Recreationally Active, Young Adults
This clinical trial aims to learn about the alterations in insulin resistance and metabolic flexibility following a transition to an obesogenic lifestyle in fit young men and women. The main questions it aims to answer are: 1. Does adding excess carbohydrates when transitioning to a sedentary lifestyle promote insulin resistance and impaired 24hr glucose regulation in healthy men and women? 2. Does adding excess carbohydrates when transitioning to a sedentary lifestyle lower the body's ability to break down fats and carbohydrates in healthy men and women? 3. Does the added physical activity blunt shifts in carbohydrate and fat oxidation in healthy men and women?
Conditions:
🦠 Insulin Resistance 🦠 Impaired Glucose Tolerance 🦠 Obesity 🦠 Metabolic Disturbance
🗓️ Study Start (Actual) 8 February 2023
🗓️ Primary Completion (Estimated) 30 September 2026
✅ Study Completion (Estimated) 30 September 2026
👥 Enrollment (Estimated) 45
🔬 Study Type INTERVENTIONAL
📊 Phase NA
Locations:
📍 Durham, New Hampshire, United States

📋 Eligibility Criteria

Description

    Inclusion Criteria:

    • * 18-30 years of age
    • * Recreationally active completing 75-150 minutes of moderate-to-vigorous intensity exercise (\>2 days/week).
    • * Fair cardiorespiratory fitness levels (Men: VO2\>38.4 ml/kg/min; Women: VO2\>32.6 ml/kg/min).

    Exclusion Criteria:

    • * Hypertension (resting or diagnosed)
    • * Impaired fasting blood glucose (\>100mg/dL)
    • * Diagnosed cardiovascular disease
    • * Diagnosed diabetes
    • * Diagnosed cancer
    • * Diagnosed chronic kidney disease
    • * Diagnosed musculoskeletal disorders that prevents the individual from exercising on a bike.
Ages Eligible for Study: 18 Years to 30 Years (ADULT)
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers: Yes

🗓️ Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

  • First Submitted 13 February 2023
  • First Submitted that Met QC Criteria 12 June 2023
  • First Posted 22 June 2023

Study Record Updates

  • Last Update Submitted that Met QC Criteria 16 July 2024
  • Last Update Posted 17 July 2024
  • Last Verified July 2024
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