THC Memory & Reward Learning Pilot
Tetrahydrocannabidiol (THC) is the psychoactive chemical in cannabis that makes people high. This study aims to dissect acute impairment of various forms of memory and learning by THC in cannabis compared to placebo. Impairment will be assessed via a short cognitive test battery and then subjects will complete four tasks in the fMRI scanner.
Conditions:
🦠 Marijuana 🦠 THC 🦠 Cannabis
🗓️ Study Start (Actual) 7 July 2022
🗓️ Primary Completion (Estimated) December 2024
✅ Study Completion (Estimated) December 2025
👥 Enrollment (Estimated) 20
🔬 Study Type INTERVENTIONAL
📊 Phase PHASE1
Locations:
📍 Hartford, Connecticut, United States

📋 Eligibility Criteria

Description

    Inclusion Criteria:

    • * 18-55 years old
    • * Right handed
    • * CNB use within past 2 years and felt "high" when used
    • * Able to read, speak, and understand English
    • * Able and willing to provide written informed consent, and willing to commit to study protocol.

    Exclusion Criteria:

    • * Current marijuana tolerance, desire to cut down, or cravings to sue during periods of abstinence.
    • * Strongly left-handed
    • * Positive screen for drug or alcohol (except CNB) on test day will result in rescheduling the appointment
    • * History of adverse effects with CNB
    • * CNB users who are abstaining
    • * Report of any psychotic disorder in a first degree relative
    • * IQ \< 80 on the Wechsler Abbreviated Scale of Intelligence
    • * Inability to comprehend written instructions using the WRAT-4 reading achievement test
    • * Pregnant, breastfeeding, and ineffective birth control methods.
    • * Unable or unsafe to have an MRI
    • * Serious medical, neuro-ophthalmological, or neurological illness (e.g. cancer, seizure disorders, encephalopathy
    • * History of head trauma with loss of consciousness \> 30 minutes or concussion lasting 30 days.
    • * Focal brain lesion seen on structural MRI
    • * Any medical/neurological condition that could compromise neurocognitive performance (e.g. epilepsy, multiple sclerosis, fetal alcohol syndrome).
    • * Anyone deemed unsafe to study personnel for any reason
Ages Eligible for Study: 18 Years to 55 Years (ADULT)
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers: Yes

🗓️ Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

  • First Submitted 28 October 2021
  • First Submitted that Met QC Criteria 8 November 2021
  • First Posted 11 November 2021

Study Record Updates

  • Last Update Submitted that Met QC Criteria 11 April 2024
  • Last Update Posted 12 April 2024
  • Last Verified April 2024