Inclusion Criteria:

• 1. CTA evidence of acute PE within ≤14 days
• 2. Clinical signs and symptoms consistent with acute PE.
• 3. Systolic BP ≥90 mmHg with evidence of dilated RV with an RV/LV ratio \>0.9 (based on Investigator's assessment of RV/LV ratio)
• 4. Stable heart rate \<130 BPM prior to procedure
• 5. Subject is between 18 and 80 years of age
• 6. Subject is willing to sign an IRB-approved informed consent form
• 7. Subject is willing and able to comply with protocol follow-up

Exclusion Criteria:

• 1. Thrombolytic use within 14 days of baseline CTA
• 2. International Normalized Ratio (INR) \>3
• 3. Platelets \<100,000/µL
• 4. Kidney dysfunction as confirmed by serum creatinine \>1.8 mg/dL or GFR \<45 mL/min
• 5. Hematocrit \<28% or hemoglobin \<9 g/dL
• 6. Systolic BP \<90 mmHg for 15 min or requirement of inotropic support to maintain systolic BP ≥90 mmHg any time after admission
• 7. Experienced cardiac arrest
• 8. Has left bundle branch block
• 9. Known bleeding diathesis or coagulation disorder
• 10. Presence of intracardiac lead in the right ventricle or right atrium
• 11. Presence of intracardiac thrombus
• 12. Major trauma within the past 14 days
• 13. Cardiovascular or pulmonary surgery within last 7 days
• 14. Known serious, uncontrolled sensitivity to radiographic agents
• 15. Contraindication to anticoagulants, i.e., heparin or alternative
• 16. Patient on extracorporeal membrane oxygenation (ECMO)
• 17. Cancer requiring active chemotherapy
• 18. Heparin-induced thrombocytopenia (HIT)
• 19. Pulmonary hypertension with peak pulmonary artery pressure \>70 mmHg by right heart catheterization.
• 20. History of chronic severe pulmonary hypertension, and/or chronic left heart disease with left ventricular ejection fraction ≤30%
• 21. Life expectancy \<90 days as determined by investigator
• 22. Pregnant or nursing
• 23. COVID-19 positive at hospital admission
• 24. Current participation in another investigational study
• 25. Evidence such as imaging or other that suggests the subject is not appropriate for this procedure (e.g., target vessel size is too small to accommodate 16F or 24F catheters).