Inclusion Criteria:

• * The participant must have a major limb amputation.
• * The participant is ≥ 18 years old at the time of consent.
• * The participant must be in generally good health to undergo a surgical intervention, as per the clinical investigator's opinion.
• * Time since the last amputation must be over a year at the time of consent.
• * The participant must have an average residual limb pain score equal or greater than 4 on the Numerical Rating Scale (NRS, 0-10) after the baseline period.
• * If the participant has been prescribed pharmacological treatments for pain, there must be no variations in dosage (steady consumption) for at least 1 month before the screening visit.
• * If the participant has been prescribed non-pharmacological treatments for pain, such as spinal cord stimulation, transcutaneous electrical nerve stimulation, and mirror therapy, the treatment must have ended at least 1 month before the screening visit.
• * The participant must have a stable prosthetic fitting for at least a month before the screening visit.
• * The participant has a sufficient understanding of the language in which the assessments will be conducted, as per the clinical investigator's opinion.

Exclusion Criteria:

• * Neurological or other conditions that affect nerve regeneration for the nerve to be treated.
• * Active infection in the residual limb.
• * Prior RPNI or TMR surgery of the nerve to be treated (with painful neuroma) to address postamputation pain.
• * Mental disorders (e.g., schizophrenia, paranoia, psychosis, etc.), reluctance, or language difficulties that result in difficulty understanding the meaning of study participation.
• * Ongoing participation in a clinical study that the clinical investigator deems detrimental to participation in this study.