Inclusion Criteria:

• * Aged 45 years or over
• * One or more vascular risk factors (e.g. high blood pressure, diabetes or vascular disease such as angina, a previous heart attack, a heart bypass or peripheral artery disease in the legs)
• * Established vascular disease (previous MI, angina, vascular stent in the peripheral bed)
• * Sufficiently fluent in written and spoken English
• * Living independently in the community
• * Willing/able to give consent to study participation.

Exclusion Criteria:

• * Current treatment with IL-1 blockade or established immune-suppressant therapy (e.g. IL-1Ra or IL-1 antibodies), or treatment within the last 3 months
• * Currently participating in a clinical trial of investigation medicinal product (CTIMP) or device trial.
• * No history of any previous ischaemic or haemorrhagic stroke, a mini-stroke or a serious brain injury
• * Do not have dementia
• * Renovascular Disease
• * Major neurological disease (immune mediated, previous brain tumors)