Inclusion Criteria:

• * At least 18 years of age or older
• * Eastern Cooperative Oncology Group (ECOG) performance status of 0-2
• * Life expectancy of at least 6 months
• * Biopsy-confirmed malignancy without gross nodal involvement of the right or left inguinal regions
• * Patients will receive elective radiation therapy to bilateral inguinal nodal regions prescribed to 45-50 Gy in 1.8-2 Gy fractions using photon or proton therapy
• * No known allergy to studied products
• * Able to give written informed consent, or have written consent given on their behalf
• * Patients who are able and willing to attend the post-radiation weekly skin assessment appointments
• * Women of childbearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control) prior to study entry and for the duration of study participation. Abstinence is acceptable if preferred by patient. Should a woman become pregnant or suspect she is pregnant while participating in this study, she must inform her treating physician immediately.

Exclusion Criteria:

• * Patients with gross cancer involvement of either or both inguinal regions.
• * Patients who have received prior pelvic and/or inguinal radiation therapy.
• * Patients who cannot apply the studied products to the inguinal region or have it administered to them as required by this study.
• * Patients with any medical condition such as active connective tissue disorder that predisposes them to an increased risk of potentially severe radiation dermatitis.
• * Patients with existing rashes or wounds in either inguinal region at baseline.
• * Planned inguinal dissection within 90 days after completion of radiation therapy on this study.
• * Female patients who are pregnant or breast feeding.
• * Patients who are unable to give written informed consent, or are unable to have written consent given on their behalf.