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Sex Disparities in Hypoxic Vasodilation and Impact of Obesity
The purpose of this project is to examine key mechanisms contributing to sex-differences in hypoxic vasodilation and the impact of obesity, with particular emphasis on the sympathetic nervous system.
Conditions:
🦠 Obesity 🦠 Vasodilation 🦠 Healthy
🗓️ Study Start (Actual) 14 March 2023
🗓️ Primary Completion (Estimated) July 2025
✅ Study Completion (Estimated) July 2025
👥 Enrollment (Estimated) 72
🔬 Study Type INTERVENTIONAL
📊 Phase EARLY_PHASE1
Locations:
📍 Columbia, Missouri, United States

📋 Eligibility Criteria

Description

    Inclusion Criteria:

    • * BMI \>18 kg/m2

    Exclusion Criteria:

    • * Pregnancy, breastfeeding
    • * Diagnosed sleep apnea or AHI \>10 events/hr
    • * Current smoking/Nicotine use
    • * Increased risk of bleeding, pro-coagulant disorders, clotting disorders, anticoagulation therapy
    • * Nerve/neurologic disease
    • * Cardiovascular, hepatic, renal, respiratory disease
    • * Blood pressure ≥140/90 mmHg
    • * Diabetes, Polycystic ovarian syndrome
    • * Communication barriers
    • * Prescription medications, Sensitivity to lidocaine
Ages Eligible for Study: 18 Years to 45 Years (ADULT)
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers: Yes

🗓️ Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

  • First Submitted 21 January 2022
  • First Submitted that Met QC Criteria 21 January 2022
  • First Posted 2 February 2022

Study Record Updates

  • Last Update Submitted that Met QC Criteria 15 February 2024
  • Last Update Posted 20 February 2024
  • Last Verified February 2024
I'm interested ...!!