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Safest Choice of Antihypertensive Regimen for Postpartum Hypertension
The purpose of this investigator-initiated randomized control trial is to determine whether oral Nifedipine versus oral Labetalol is superior in controlling high blood pressures in the postpartum period.
Conditions:
🦠 Postpartum Complication 🦠 Maternal Hypertension 🦠 High Blood Pressure
🗓️ Study Start (Actual) December 2024
🗓️ Primary Completion (Estimated) December 2027
✅ Study Completion (Estimated) December 2027
👥 Enrollment (Estimated) 500
🔬 Study Type INTERVENTIONAL
📊 Phase PHASE3
Locations:
📍 Loma Linda, California, United States

📋 Eligibility Criteria

Description

    Inclusion Criteria:

    • * Female
    • * Women who develop postpartum hypertension\* after delivery of the placenta or chronic hypertensive postpartum women who require medication for blood pressure control.
    • * Postpartum hypertension requiring treatment are defined as systolic blood pressure greater than or equal to 140mmHg or diastolic blood pressure greater than or equal to 90mmHg on at least 2 occasions at least 4 hours apart, or systolic blood pressure greater than or equal to 160mmHg or diastolic blood pressure greater than 110mmHg sustained for more than 15 minutes.

    Exclusion Criteria:

    • * History of moderate persistent asthma, coronary artery disease, heart failure, AV heart block, pulmonary edema
    • * Contraindication to either Nifedipine or Labetalol
    • * HR \<60 or \>110
    • * Native language other than English or Spanish
Ages Eligible for Study: 18 Years to N/A (ADULT, OLDER_ADULT)
Sexes Eligible for Study: FEMALE
Accepts Healthy Volunteers: No

🗓️ Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

  • First Submitted 19 September 2022
  • First Submitted that Met QC Criteria 19 September 2022
  • First Posted 22 September 2022

Study Record Updates

  • Last Update Submitted that Met QC Criteria 3 May 2024
  • Last Update Posted 6 May 2024
  • Last Verified May 2024
I'm interested ...!!