Description
Inclusion Criteria:
- 1. Current or past history of drug injection;
- 2. Health insurance that will cover HCV medications (study staff will work with those who are eligible but have not signed up for insurance prior to study enrollment)
- 3. Lives in one of the study counties in NH and VT, and plans to remain in the study region for the next 12 months;
- 4. Age 18 years or older;
- 5. Speaks English;
- 6. Capacity to voluntarily provide informed consent;
- 7. Will accept randomized assignment, and participate in follow-up over 12 months;
- 8. Will provide releases to access community medical records;
- 9. Will provide names and contact information of at least 3 persons for re-contact purposes;
- 10. Not previously treated for HCV;
- 11. Not pregnant or trying to conceive;
- 12. HCV antibody positive on point-of-care rapid test.
Exclusion Criteria:
- 1. Unable to obtain venous blood sample for mandatory laboratory testing
- 2. HCV viral load undetectable
- 3. Hepatitis B surface antigen (HBsAg) positive;
- 4. Significant renal failure (eGFR 30 mL/min/1.73m2 or less, or end-stage renal disease requiring dialysis);
- 5. Decompensated cirrhosis, as manifested by liver fibrosis on elastography (FibroScan) and/or Fibrosure blood test plus at least one of the following symptoms:
- i. Observed jaundice (yellowing of the eyes and skin) ii. Self-reported increasing abdominal size (ascites) and leg edema iii. Observed periods of confusion consistent with encephalopathy iv. Self-reported history of gastrointestinal bleeding.
Ages Eligible for Study:
18 Years to N/A (ADULT, OLDER_ADULT)
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers:
Yes