Inclusion Criteria:

• * Patient is 18 years of age or older
• * Patient is undergoing endoscopic endonasal approach for the management of a skull base tumor or cerebrospinal fluid leak. Nasoseptal Flap must be harvested.
• * Patient is undergoing surgery via bi-nostril approach requiring bilateral surgical dissection of the nasal cavity in approach to the skull base

Exclusion Criteria:

• * Patient has evidence of radiographic baseline sinus disease consistent with acute or chronic rhinosinusitis (including nasal polyposis, prior septal perforation) on pre-operative CT sinus
• * Patient has had prior sinonasal surgery or has undergone sinonasal radiation treatment
• * Patient has a known coagulation disorder or immune deficiency.