Reversal of Battle-Related Aging (ROBRA) in a Special Operations Forces Cohort
The purpose of this study is to examine measures of GrimAge clock in SOF members undergoing treatment for PTSD/TBI using CSB.
Conditions:
🦠 Post-Traumatic Stress Disorder 🦠 Traumatic Brain Injury
🗓️ Study Start (Actual) 5 July 2023
🗓️ Primary Completion (Estimated) 5 April 2024
✅ Study Completion (Estimated) 5 April 2024
👥 Enrollment (Estimated) 20
🔬 Study Type OBSERVATIONAL
📊 Phase N/A
Locations:
📍 Westmont, Illinois, United States

📋 Eligibility Criteria

Description

    Inclusion Criteria:

    • * Recruited from SOF with an active duty history of at least 5 years.
    • * Subjects may be in active duty or retired, male and female, between the ages of 40 and 60 years old.
    • * The participants must have a confirmed diagnosis of PTSD, identified by Posttraumatic Stress Disorder Checklist for DSM-5 (PCL-5) scores higher than 40.
    • * The participants must have been on a stable pharmacological or psychotherapeutic therapy for at least three months (if applicable), and continue this treatment throughout the duration of the study.
    • * They must be able and willing to consent for the study. Individuals who are able to become pregnant must adhere to a medically accepted method of contraception (eg. hormonal birth control, barrier birth control, intrauterine device, abstinence).

    Exclusion Criteria:

    • * Existing Horner syndrome;
    • * Allergy to local anesthetics or contrast;
    • * Previous history of stellate ganglion block with psychosis;
    • * Admission to in-patient psychiatric facility within last 3 months;
    • * History of moderate of severe TBI;
    • * Currently pregnant or breastfeeding;
    • * Current substance use disorder, or test positive for 1 or more illegal or controlled drugs on the initial urine drug screen, such as cocaine, marijuana, amphetamines, opioids, benzodiazepines, amongst others;
    • * Previous behavioral health diagnoses (bipolar I, psychosis, etc);
    • * Currently undergoing exposure therapy.
Ages Eligible for Study: 40 Years to 60 Years (ADULT)
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers: No

🗓️ Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

  • First Submitted 21 April 2023
  • First Submitted that Met QC Criteria 2 May 2023
  • First Posted 12 May 2023

Study Record Updates

  • Last Update Submitted that Met QC Criteria 13 July 2023
  • Last Update Posted 17 July 2023
  • Last Verified July 2023