Inclusion Criteria:

• 1. Female sex
• 2. Patient is at least 18 years old.
• 3. Multivessel or left main CAD is present for which revascularization is intended and for which there is equipoise between CABG and PCI according to local Heart Team assessment.
• 4. Ability to provide written informed consent and comply with all follow-up procedures, including QOL questionnaires.

Exclusion Criteria:

• 1. ST-segment elevation MI within 3 days
• 2. Cardiogenic shock
• 3. Prior PCI within 1 year or any prior CABG anytime
• 4. Planned hybrid revascularization (PCI after CABG or CABG after PCI)
• 5. Planned single vessel revascularization (other than isolated left main disease)
• 6. Need for any cardiac surgical or interventional procedure other than coronary revascularization at the present time or anticipated within 3 years
• 7. Pregnancy (women of child-bearing potential must have a negative pregnancy test within 1 week before randomization) or intent to become pregnant within 1 year after randomization
• 8. Unable to tolerate, obtain or comply with dual antiplatelet therapy for at least 3 months if presentation with stable CAD or 6 months if presentation with a troponin-positive acute coronary syndrome
• 9. Current participation in another investigational drug or device study that has not reached its primary endpoint
• 10. Life-expectancy less than 3 years due to concomitant non-cardiac conditions
• 11. Any condition(s) are present that are likely to interfere with the study protocol procedures including medication adherence and follow-up through 10 years (e.g. mental disability, substance abuse, anticipated international relocation, etc.)