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Renal Metabolism in Salt-sensitive Human Blood Pressure
Salt sensitive hypertension is a significant health problem worldwide and a primary modifiable risk factor for renal, cardiovascular, and cerebrovascular diseases. Yet, the underlying mechanisms remain poorly understood. The proposed study determines how renal oxygenation and substrate metabolism differs between individuals with and without salt sensitivity, with the ultimate goal of identifying mechanisms, diagnostic criteria, and treatment strategies for salt sensitive hypertension.
Conditions:
🦠 Hypertension
🗓️ Study Start (Actual) 1 November 2021
🗓️ Primary Completion (Estimated) 30 January 2030
✅ Study Completion (Estimated) 30 January 2030
👥 Enrollment (Estimated) 70
🔬 Study Type INTERVENTIONAL
📊 Phase NA
Locations:
📍 Milwaukee, Wisconsin, United States

📋 Eligibility Criteria

Description

    Inclusion Criteria:

    • * English speaking subjects
    • * With a spectrum of BPs, ranging from those with Elevated BP through Stage 1 HTN, as defined by the 2017 ACC/AHA HTN guidelines

    Exclusion Criteria:

    • * Non-English speakers
    • * BP ≤120/80 \& ≥ 140/90 mmHg
    • * H/o diabetes, congestive heart failure, cirrhosis of the liver, hypokalemia \& other
    • * electrolyte disturbances
    • * H/o kidney disease
    • * Use of glucocorticoids
    • * Pregnant or nursing mothers
    • * Presence of bleeding disorders
    • * Use of anti-platelet and anticoagulant agents such as clopidogrel, aspirin, dabigatran, rivaroxaban etc
    • * Daily sodium intake ≥ 6000 mg/day
    • * Presence of pacemaker or other metallic implants
    • * Allergy to iodinated contrast
    • * Allergy to shellfish
    • * Claustrophobia
Ages Eligible for Study: 30 Years to 65 Years (ADULT, OLDER_ADULT)
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers: No

🗓️ Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

  • First Submitted 6 May 2022
  • First Submitted that Met QC Criteria 10 May 2022
  • First Posted 11 May 2022

Study Record Updates

  • Last Update Submitted that Met QC Criteria 23 May 2022
  • Last Update Posted 25 May 2022
  • Last Verified May 2022
I'm interested ...!!