Racial Differences in Serum Sodium and Blood Pressure Regulation

RECRUITING

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Nearly nine-in-ten Americans overconsume salt. Black individuals are more prone to salt-sensitive hypertension. The central goal of the study is to determine if dietary sodium influences blood vessel function and nervous system regulation of blood pressure differentially in black, compared to white individuals. These findings may help to explain why high dietary salt causes increases in blood pressure more frequently in black, compared to white individuals. A secondary goal of this project is to also determine the role of lifestyle factors (i.e., sleep, physical activity, and nutrition) on potential baseline racial differences in cardiovascular function.

Conditions:

🦠 Sodium Excess 🦠 Racial Disparities 🦠 Blood Pressure 🦠 Cardiovascular Risk Factor

🗓️ Study Start (Actual) 3 May 2021

🗓️ Primary Completion (Estimated) 31 August 2024

✅ Study Completion (Estimated) 31 May 2025

👥 Enrollment (Estimated) 100

🔬 Study Type INTERVENTIONAL

📊 Phase NA

Locations:

📍 Auburn, Alabama, United States

📋 Eligibility Criteria

Description

Inclusion Criteria:

1. Are between the ages of 19-75.
2. Have blood pressure no higher than 150/90 mmHg.
3. Have a BMI below 35 Kg/m2 (otherwise healthy)
4. Free from metabolic disease (diabetes or renal disease), pulmonary disorders (e.g., COPD \& cystic fibrosis), and cardiovascular disease (peripheral vascular, cardiac, or cerebrovascular).
5. Do not have any precluding medical issues that prevent participants from exercising (i.e., cardiovascular issues, or muscle/joint issues including painful arthritis) or giving blood (e.g., blood thinners).
6. Are not currently smoking, using smokeless tobacco, nor smoked within the past 12 months.

Exclusion Criteria:

1. High blood pressure - greater the 150/90 mmHg
2. Low blood pressure - less than 90/50 mmHg
3. History of cardiovascular disease
4. History of cancer
5. History of diabetes
6. History of kidney disease
7. Obesity (BMI \> 30 kg/m2)
8. Smoking or tobacco use
9. Current pregnancy
10. Nursing mothers
11. Communication barriers

Ages Eligible for Study: 19 Years to 75 Years (ADULT, OLDER_ADULT)

Sexes Eligible for Study: ALL

Accepts Healthy Volunteers: Yes

🗓️ Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

First Submitted 5 December 2019
First Submitted that Met QC Criteria 24 January 2020
First Posted 28 January 2020

Study Record Updates

Last Update Submitted that Met QC Criteria 14 August 2023
Last Update Posted 15 August 2023
Last Verified August 2023