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Purinergic Signaling and the Postmenopausal Heart
There is an increased risk of diastolic heart failure in post menopausal women. Estrogen plays a positive role in regulating molecular pathways in heart remodeling. Such pathways may work through purinergic signaling and its downstream effects on the heart's mitochondrial metabolism and angiogenic response to stress. Loss of estrogen functionality in post menopausal women may account for the increased risk of diastolic heart failure. The investigators will explore said pathways using cardiac tissue obtained from patients undergoing cardiac surgery.
Conditions:
🦠 Diastolic Heart Failure 🦠 Heart Failure With Preserved Ejection Fraction
🗓️ Study Start (Actual) 1 July 2019
🗓️ Primary Completion (Estimated) June 2024
✅ Study Completion (Estimated) June 2024
👥 Enrollment (Estimated) 100
🔬 Study Type OBSERVATIONAL
📊 Phase N/A
Locations:
📍 Boston, Massachusetts, United States

📋 Eligibility Criteria

Description

    Inclusion Criteria:

    • * Patients undergoing cardiac surgery under cardiopulmonary bypass.

    Exclusion Criteria:

    • * Refusal to participate
    • * Emergency surgery
    • * Pre-existing heart block
    • * Preexisting atrial fibrillation
    • * Redo surgery
    • * Estrogen or hormone replacement therapy
    • * History of chronic heart failure
    • * History of major kidney disease
Ages Eligible for Study: 30 Years to 88 Years (ADULT, OLDER_ADULT)
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers: No

🗓️ Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

  • First Submitted 23 August 2023
  • First Submitted that Met QC Criteria 28 August 2023
  • First Posted 29 August 2023

Study Record Updates

  • Last Update Submitted that Met QC Criteria 28 August 2023
  • Last Update Posted 29 August 2023
  • Last Verified August 2023
I'm interested ...!!