Inclusion Criteria:

• * Patients with biopsy proven newly diagnosed rhabdomyosarcoma.
• * Patients less than or equal to 21 years of age.
• * Patients must be treated with a standardly accepted chemotherapy regimen.
• * May not have metastatic disease unless aged 2-10 with embryonal histology.
• * Must be willing to receive follow-up care for a minimum of five years after treatment at MGH and annual visits unless it is too difficult to return to MGH for follow-up care. In that event, they must be willing to have their outside medical information released to us to track the results.
• * Timing of radiation must be according to the IRB protocol upon which the patient is treated within either 35 days of last chemotherapy or surgery.

Exclusion Criteria:

• * Life expectancy of less than 2 years.
• * Co-morbidities that would make the use of radiation too toxic to deliver safely, such as serious local injury or collagen vascular disease.
• * Patients who are pregnant
• * Previous treatment with radiation therapy.