Inclusion Criteria:

• * Clinical Stage ≤ T2c
• * PSA ≤ 20 ng/ml
• * Prostate volume ≥ 30 ml
• * Grade Group (GG) 1 or 2: If GG 1: ≥ 3 cores positive for cancer. Note, multiple positive from any MRI targeted lesion will be considered as a single positive core.

Exclusion Criteria:

• * Any prior or current treatment for prostate cancer, including but not limited to surgery, radiation therapy (external or brachytherapy), tissue ablation or chemotherapy.
• * Patients with previous surgical or minimally invasive treatment of benign prostatic hyperplasia within the prior 12 months.
• * Radiographically suspicious lymph node involvement confirmed with biopsy or PET scan.
• * Evidence of bone metastasis.
• * Evidence of extracapsular involvement.
• * Evidence of seminal vesicle invasion on DRE or MRI read as "definite", "probable" or "consistent with"
• * Any condition or history of illness or surgery that may pose an additional risk to men undergoing the Aquablation procedure.