Preventing Cognitive Decline by Reducing BP Target Trial
The PCOT study is a multi-site randomized trial of patients 70 years or older with high BP. The main goal of the study Preventing Cognitive Decline by Reducing BP Target Trial (PCOT) is to conduct a large pragmatic clinical trial (PCT) to test the hypothesis that patients who receive care with a combination of clinical decision support (CDS) and team-based care delivered in primary care practices will have better blood pressure control and a lower incidence of mild cognitive impairment and dementia than patients receiving usual medical care. Patients will be recruited from UT Southwestern Medical Center and Parkland Health \& Hospital System.
Conditions:
🦠 Cognitive Decline 🦠 Blood Pressure 🦠 Hypertension
🗓️ Study Start (Actual) 11 July 2022
🗓️ Primary Completion (Estimated) 31 August 2025
✅ Study Completion (Estimated) 31 August 2025
👥 Enrollment (Estimated) 4000
🔬 Study Type INTERVENTIONAL
📊 Phase NA
Locations:
📍 Dallas, Texas, United States

📋 Eligibility Criteria

Description

    Inclusion Criteria:

    • * High BP defined as at least 1 BP readings of SBP \>= 130 or DBP \>=80 during the 24 months prior to enrollment
    • * Clinic visit with primary care provider within the last 24 months
    • * Ability to write and speak English or Spanish
    • * 70 years of age or older
    • * Ability to understand and willingness to provide informed consent
    • * Owns a smartphone

    Exclusion Criteria:

    • * Blood pressure consistently \<130/80 mmHg
    • * Presence of dementia, Alzheimer's disease, or significant neurological disease
    • * Major and unstable heart disease (e.g., acute heart failure (systolic or diastolic), acute on chronic heart failure (systolic or diastolic), acute coronary syndrome or cardiac arrest, liver or renal transplantation
    • * Under 70 years of age
    • * Inability to write or speak English or Spanish
    • * Chronic kidney disease stage 5 or ESKD
    • * Chemotherapy
    • * Any conditions judged by the medical providers to contraindicate participation due to risk to patient safety or lack of adherence
    • * Expected life expectancy under a year
Ages Eligible for Study: 70 Years to N/A (OLDER_ADULT)
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers: No

🗓️ Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

  • First Submitted 27 September 2021
  • First Submitted that Met QC Criteria 22 October 2021
  • First Posted 3 November 2021

Study Record Updates

  • Last Update Submitted that Met QC Criteria 27 October 2023
  • Last Update Posted 31 October 2023
  • Last Verified October 2023