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Precision Analgesia for Cardiac Surgery
The proposed research is an important extension of an ongoing perioperative personalized analgesia and intravenous opioid pharmacogenetic research. This research focuses on two of the most commonly used oral opioid analgesics, oxycodone, and methadone in elderly adults undergoing cardiac surgery.
Conditions:
🦠 Analgesia 🦠 Cardiac Surgery
🗓️ Study Start (Actual) 1 April 2025
🗓️ Primary Completion (Estimated) 1 December 2026
✅ Study Completion (Estimated) 1 December 2026
👥 Enrollment (Estimated) 400
🔬 Study Type OBSERVATIONAL
📊 Phase N/A
Locations:
📍 Pittsburgh, Pennsylvania, United States

📋 Eligibility Criteria

Description

    Inclusion Criteria:

    • * Elderly cardiac surgical patients over 60 years of age

    Exclusion Criteria:

    • * Methadone allergy
    • * Morbid obesity (BMI \>40kg/cm2)
    • * Severe sleep apnea
    • * Severe pulmonary disease requiring oxygen therapy
    • * Preoperative mechanical circulatory support
    • * Emergency surgery
    • * Liver disease (liver enzymes more than two times normal)
    • * End-stage renal disease requiring dialysis
    • * Serum creatinine more than 2.0mg
Ages Eligible for Study: 60 Years to 110 Years (ADULT, OLDER_ADULT)
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers: No

🗓️ Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

  • First Submitted 3 November 2022
  • First Submitted that Met QC Criteria 3 November 2022
  • First Posted 10 November 2022

Study Record Updates

  • Last Update Submitted that Met QC Criteria 21 May 2024
  • Last Update Posted 23 May 2024
  • Last Verified May 2024
I'm interested ...!!