Description
Inclusion Criteria:
- i) Age range 20 yrs to 50 yrs; ii) BMI \> 30 kg/m2 to 55kg/m2; iii). Fasting blood glucose \>126 mg/dl and 2 hour glucose \>200 mg/dl determined by OGTT; iv). HbA1c \> 6.5 % to ≤10%.
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Exclusion Criteria:
- i) Proteinuria or elevated serum creatinine (\>1.5 mg/dl); ii) Surgical or premature menopause; iii) liver disease or abnormal liver function tests; iv) T2DM of greater than 2 yrs; v) Thyroid disease with abnormal TSH; vi) Weight \> 350 lbs, (due to fit on DXA); vii) Triglycerides\>400 mg/dl or LDL cholesterol \>160 mg/dl; viii) SBP\>145, DBP\>100 mm of Hg; ix) on medications known to effect lipid or glucose metabolism; x) Pregnancy or become pregnant in next 6 mo; xi) Weight loss \>10% of body weight in last 6 mo; xii)History of cancer \<5 yrs or undergoing active treatment; xiii) smoking, xiv)alcohol abuse; xv) having CPAP treatment. xvi)Subjects with HbA1c \>10% will be referred to an endocrinologist for pharmacological treatment.
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Ages Eligible for Study:
20 Years to 50 Years (ADULT)
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers:
Yes