Inclusion Criteria:

• * Adult patients, age ≥18 and \<85 years
• * Experience prolonged, non-trauma-related in-hospital cardiac arrest, defined by cessation of heartbeat and respiration requiring CPR for at least 10 minutes

Exclusion Criteria:

• * Age \<18 years old
• * Age \> 85 years old
• * Patients with DNR/DNI orders (Do Not Resuscitate/Do Not Intubate)
• * Patients admitted to the hospital with a cardiac arrest arising from trauma
• * Patients who achieve return of spontaneous circulation within 10 minutes of CPR
• * Inability to start study product administration within 20 minutes of cardiac arrest onset
• * Prisoners
• * Women who are known to be pregnant
• * Patients with a history of RBC antibodies or positive antibody screen prior to enrollment in the study, unless previously cross-matched units are available for transfusion.
• * Patients with ultrasound evidence of right ventricular dilatation at time of CA
• * Patients with known prior objection to receipt of blood products.
• * Patients for whom administration of additional fluid volume is contraindicated (as determined by physician responsible for care)
• * Physician objection based on concern that intervention would interfere with patient care plan