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OCT Vibrography for Biomechanical Properties of Tissues
The overall goal of this study is to develop OCT Vibrography (aka OCT elastography) as a novel tool for measuring biomechanical properties of human tissues in vivo.
Conditions:
🦠 Cornea 🦠 Skin Diseases 🦠 Gingival Diseases
🗓️ Study Start (Actual) 19 August 2023
🗓️ Primary Completion (Estimated) 28 August 2026
✅ Study Completion (Estimated) 28 August 2026
👥 Enrollment (Estimated) 90
🔬 Study Type INTERVENTIONAL
📊 Phase NA
Locations:
📍 Boston, Massachusetts, United States

📋 Eligibility Criteria

Description

  • Group 1:

    • Inclusion Criteria:

    • • Subjects with healthy eyes (age 18 - 75, N = 50)

    Exclusion Criteria:

    • * Subjects with history of eye diseases, and previous eye surgeries.
    • * Subjects with diabetes, glaucoma family history
    • * Subjects allergic to anesthetic eyedrop, especially proparacaine
    • * Subjects with severe allergy
    • * Subjects who have difficulty biting
    • * Subjects who have recurrent corneal erosion
    • Group 2:

    Inclusion Criteria:

    • • Subjects with healthy skin (age 18 - 75, N = 10)

    Exclusion Criteria:

    • • Subjects with open cuts/sores on the skin, skin infection, or any contagious skin condition
    • Group 3:

    Inclusion Criteria:

    • • Subjects with healthy gingiva (age 18 - 75, N = 10)

    Exclusion Criteria:

    • • Subjects with open cuts/sores on the gingiva, gingiva infection, or any contagious gingiva condition
    • Group 4:

    Inclusion Criteria:

    • • Mild or moderate keratoconus subjects (age 18 - 40, N = 20)

    Exclusion Criteria:

    • • Subjects with K-max above 60 diopters (Pentacam imaging) are excluded
Ages Eligible for Study: 18 Years to 75 Years (ADULT, OLDER_ADULT)
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers: Yes

🗓️ Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

  • First Submitted 26 February 2023
  • First Submitted that Met QC Criteria 26 February 2023
  • First Posted 8 March 2023

Study Record Updates

  • Last Update Submitted that Met QC Criteria 11 March 2024
  • Last Update Posted 13 March 2024
  • Last Verified March 2024
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