Description
Inclusion Criteria:
- 1. Has T2DM, as indicated by any of the following:
- 1. Self-report of diabetes plus the use of a prescribed diabetes medication.
- 2. ICD-10 code for diabetes plus current use of a diabetes medication in the electronic medical record.
- 3. HbA1c \>6.4%; or 2 fasting glucose \> 125 mg/dL
- 2. Fasting morning UACR between 100 and 2,000 mg/g creatinine on two separate days
- 3. If UACR is \> 300 mg/g creatinine, must be currently using an ACE inhibitor or an ARB
- 4. eGFR \> 30 mL/ min / 1.73 m2
- 5. Hemoglobin A1c \<9%
- 6. Able to speak English or Spanish
- 7. Willing and able to provide written informed consent
- 8. In addition, female participants must Not be pregnant and not planning to become pregnant over the next 6 months
Exclusion Criteria:
- 1. Fasting morning UACR \> 2,000 mg/ g creatinine
- 2. Other laboratory abnormalities:
- 1. Has AST or ALT \> 3 times the upper limit of normal
- 2. creatinine \> 2.5 mg/dL
- 3. Hematocrit \< 0.34 or 0.50 L/L
- 3. A major adverse cardiovascular event in preceding 3 months
- 4. Participation in an investigational trial to evaluate pharmaceuticals or biologics within the past 3 months or 5 half-lives, whichever is shorter
- 5. Hypoglycemia unawareness or other medical conditions which could jeopardize participant's safety.
- 6. History of alcohol or substance use disorder or dependence (DSM 5 criteria) within the last 2 years.
- 7. Major depressive disorder, bipolar disorder, schizophrenia, or current psychotic symptoms or behavioral problems that could interfere with study procedures.
- 8. BMI \> 42.5 kg/ m2
Ages Eligible for Study:
60 Years to N/A (ADULT, OLDER_ADULT)
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers:
No