Description
- Inclusion Criteria for symptomatic patient cohort
- * Patients must be 18 years of age or older, able to provide written informed consent, and ability to lie still for PET scanning.
- * Suspected knee prosthetic infection at least 2 months after original prosthesis placement and who are scheduled to undergo surgery debridement/removal based on the clinical assessment of the referring surgeon.
- * Elevated CRP and ESR
- Exclusion Criteria for symptomatic patient cohort:
- * Undergoing current or recent antimicrobial therapy (within 1 month)
- * Significant comorbidity such as renal failure, septic shock, uncontrolled diabetes
- * Other clinically likely site of infection
- Inclusion Criteria for asymptomatic cohort:
- * Patients must be 18 years of age or older, able to provide written informed consent and ability to lie still for PET scanning
- * Knee prosthesis in situ without complications for 6 months or longer
- Exclusion Criteria for asymptomatic cohort:
- * Clinical or laboratory suspicion of knee prosthesis infection
- * Recent (within 3 months) or current treatment for infected knee prosthesis
- * Significant comorbidity such as renal failure, septic shock, uncontrolled diabetes
Ages Eligible for Study:
18 Years to N/A (ADULT, OLDER_ADULT)
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers:
Yes