Description
Inclusion Criteria:
- In order to be eligible to participate in this study, an individual must meet all of the following criteria:
- 1. Meets one of the following:
- 1. Has documentation of PID confirmed by genetic evaluation demonstrating a deleterious variant in the gene (or genes) known to be associated with immune deficiency (confirmed PID); or
- 2. Has documented variant of undetermined significance in a gene (or genes) that is predicted to be deleterious in immune function by the investigators AND a clinical history of infections which are more frequent, more chronic, or more severe than normal (suspected PID); or
- 3. Has physician-diagnosed psoriasis; or
- 4. Has physician-diagnosed AD; or
- 5. Does not have clinically apparent evidence of any monogenic or digenic immune defect, AD, or psoriasis (healthy volunteers).
- 2. Aged 18 to 75 years.
- 3. Willing to allow storage of blood, biopsy tissue, and bacterial and fungal cultures for future research.
- 4. Able to provide informed consent.
Exclusion Criteria:
- An individual who meets any of the following criteria will be excluded from participation in this study:
- 1. Current or prior (within 3 months) anticoagulant or anti-platelet therapy (other than aspirin or non-steroidal anti-inflammatory drugs).
- 2. Current or prior (within 3 months) use of immunomodulatory drugs (eg, chemotherapy, steroids), except if approved by the principal investigator.
- 3. History of keloid formation.
- 4. Pregnancy, lactating, or breastfeeding.
- 5. Any condition that, in the opinion of the investigator, contraindicates participation in the study.
Ages Eligible for Study:
18 Years to 75 Years (ADULT, OLDER_ADULT)
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers:
Yes