Inclusion Criteria:

• * Overweight or obese males and females BMI 25 kg/m2 to 40 kg/m2
• * Age 18 years and older
• * Diagnosed with obstructive sleep apnea by Apnea-Hypopnea Index \>15 events/hr using 4% oxygen desaturation criteria and \< 25% central events/hr on prior sleep testing Data can be derived from home sleep testing or in-lab polysomnogram
• * Absent circumferential collapse on Drug-Induced Sleep Endoscopy (DISE)
• * Not able to use positive airway pressure \>4 hours for 5 nights/week or unwilling to use positive airway pressure
• * Weight stable (no change \>25 lbs in the past 3 months)

Exclusion Criteria:

• * Insulin-dependent Diabetes
• * Inability to undergo in-lab polysomnography or home sleep testing
• * Central Nervous System (CNS) disease with impairment of cognitive function (dementia) and/or muscle paresis, such as stroke
• * Currently pregnant, trying to get pregnant or nursing
• * age \< 18 years
• * Regular and adherent CPAP use per clinical guidelines
• * Current night shift or rotating shift work
• * Diagnosis of another sleep disorder (e.g. periodic limb movement disorder)
• * Enrolled in a formal weight loss program or following an incompatible dietary regimen
• * Current systemic steroid use
• * Taking prescription medication or herbal remedy for weight loss
• * Predominantly central sleep apnea or requiring oxygen or bi-level positive airway pressure or advanced positive airway pressure modalities
• * Protected patient: under guardianship, curatorship or other legal protection, deprived of liberty by judicial or administrative decision, including hospitalized without consent