Inclusion Criteria:

• 1. Meet American College of Rheumatology (ACR) criteria for SLE
• 2. Report NPSLE symptoms on the screening survey recommended by EULAR guideline but limited to the psychiatric manifestations questions
• 3. Score ≤ 85 on the RBANS total index (≤ 1 SD below the normative mean of 100)

Exclusion Criteria:

• 1. Male and female subjects \<18 or \>60 years
• 2. Change in medication that may affect mood or cognition including prednisone, antidepressant medications, or stimulants within the last 4 weeks
• 3. Regular (daily) use of opioids or other drugs of abuse including heavy alcohol or marijuana use
• 4. Metabolic derangement defined as liver function tests \>3x upper limit of normal or severe renal disease defined as calculated creatinine clearance \<30 mL
• 5. Severe psychiatric disease including schizophrenia, psychosis, suicidal depression
• 6. Other factors which in the opinion of the investigator could potentially impact the study outcomes (e.g., underlying disease, medications, history)\* or prevent the participant from completing the protocol (poor compliance or unpredictable schedule)
• 7. Inability or refusal to give informed consent for any reason including a diagnosis of dementia or significant cognitive impairment\*\*
• 8. Patients who are pregnant
• 9. Patients who are enrolled in other investigational drug studies