Mediators of Atherosclerosis in South Asians Living in America

RECRUITING

I'm interested ...!!

South Asian (Indian, Pakistani, Bangladeshi, Nepali, and Sri Lankan) individuals have high rates of cardiovascular disease that is not explained by traditional cardiovascular risk factors. Though South Asians represent over one-quarter of the world's population, there are no longitudinal studies in this high-risk ethnic group. The investigators aim to establish a longitudinal study of South Asians at three United States centers to identify risk factors linked to subclinical atherosclerosis and incident cardiovascular disease. The purpose of this study is to understand the causes of heart disease and stroke in South Asians and compare these causes to those in other United States ethnic groups.

Conditions:

🦠 Atherosclerosis 🦠 Cardiovascular Diseases 🦠 Heart Diseases 🦠 Coronary Artery Disease 🦠 Coronary Disease

🗓️ Study Start (Actual) September 2010

🗓️ Primary Completion (Estimated) March 2013

✅ Study Completion (Estimated) December 2025

👥 Enrollment (Estimated) 2314

🔬 Study Type OBSERVATIONAL

📊 Phase N/A

Locations:

📍 San Francisco, California, United States

📍 Chicago, Illinois, United States

📍 New York, New York, United States

📋 Eligibility Criteria

Description

Inclusion Criteria:

* South Asian ancestry defined by having at least 3 grandparents born in one of the following countries: India, Pakistan, Bangladesh, Nepal, or Sri Lanka
* age between 40 and 84 years.

Exclusion Criteria:

* Physician diagnosed heart attack, stroke or transient ischemic attack (TIA), heart failure, or angina (or use of nitroglycerin)
* Current atrial fibrillation
* Past history of cardiovascular procedures (coronary artery bypass graft (CABG) Surgery, angioplasty, valve replacement, pacemaker or defibrillator implantation, or any surgery on the heart or arteries)
* Active treatment for cancer
* Life expectancy less than 5 years due to serious medical illness
* Impaired cognitive ability as judged by the reviewer
* Plans to move out of the study region in next 5 years
* Weight greater than 300 pounds
* Living in a nursing home or on a waiting list
* Unable to speak/read/write English, Hindi, Urdu, or Bangla

Ages Eligible for Study: 40 Years to 84 Years (ADULT, OLDER_ADULT)

Sexes Eligible for Study: ALL

Accepts Healthy Volunteers: No

🗓️ Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

First Submitted 21 September 2010
First Submitted that Met QC Criteria 21 September 2010
First Posted 22 September 2010

Study Record Updates

Last Update Submitted that Met QC Criteria 5 March 2024
Last Update Posted 7 March 2024
Last Verified March 2024