Inclusion Criteria:

• 1. Male or female participants ≥6 to 65 yrs of age
• 2. Meet AD Standard Diagnostic Criteria

Exclusion Criteria:

• 1. Enrollment in another clinical trial
• 2. Hypersensitivity to an agent used for the skin decolonization protocol
• 3. Use within 4 weeks of systemic treatment with immunosuppressive/immunomodulating drugs (corticosteroids, cyclosporine, mycophenolate, JAK inhibitors, azathioprine, methotrexate)
• 4. Phototherapy for AD within 4 weeks
• 5. Treatment with biologics (dupilumab, omalizumab, benralizumab, etc) within sixteen weeks
• 6. Use of topical steroids, topical calcineurin inhibitors or crisaborale within 7 days
• 7. Bleach baths within 7 days of the first Visit
• 8. Use of oral or topical antibiotics within 21 days of the beginning of the study
• 9. Asthmatics receiving more than 500 μg per day of inhaled corticosteroids
• 10. History of (HIV, hepatitis B, hepatitis C, tuberculosis malignancy
• 11. Skin comorbidities that may interfere with assessments: psoriasis, cutaneous T Cell lymphoma,,
• 12. Severe ongoing medical illnesses e.g. cardiovascular, renal disease, autoimmune disease.
• 13. Febrile illness at time of visits
• 14. Suspected immune deficiency or family history of primary immunodeficiency