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Mechanisms of Exercise Intolerance in Heart Failure With Preserved Ejection Fraction
The global objective of this study is to determine the mechanisms of exercise intolerance and dyspnea on exertion (DOE) in patients with HFpEF and based on this pathophysiology, test whether specific exercise training programs (whole body vs single leg) will result in improved exercise tolerance.
Conditions:
🦠 Heart Failure, Diastolic
🗓️ Study Start (Actual) 1 August 2019
🗓️ Primary Completion (Estimated) 1 July 2025
✅ Study Completion (Estimated) 31 December 2025
👥 Enrollment (Estimated) 100
🔬 Study Type INTERVENTIONAL
📊 Phase NA
Locations:
📍 Dallas, Texas, United States

📋 Eligibility Criteria

Description

    Inclusion Criteria:

    • * signs and symptoms of heart failure
    • * an ejection fraction \> 0.50
    • * objective evidence of diastolic dysfunction

    Exclusion Criteria:

    • * age \< 60 years
    • * BMI \> 50 kg/m2
    • * PDE5 inhibitor use
    • * Severe valvular disease
    • * Severe COPD
    • * CKD 4 or higher
    • * Contra-indication to MRI.
Ages Eligible for Study: 60 Years to 90 Years (ADULT, OLDER_ADULT)
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers: No

🗓️ Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

  • First Submitted 22 August 2019
  • First Submitted that Met QC Criteria 23 August 2019
  • First Posted 28 August 2019

Study Record Updates

  • Last Update Submitted that Met QC Criteria 18 June 2024
  • Last Update Posted 21 June 2024
  • Last Verified June 2024
I'm interested ...!!