Inclusion Criteria:

• -
• Adult nonsmokers, aged 21-50, who:
• * Are healthy on the basis of medical history
• * Have systolic blood pressure \<150
• * Have diastolic blood pressure \<100
• * Have BMI between 18.1 and 34.9
• * Able to perform moderate exercise,
• * Are not exposed to tobacco or cannabis SHS in their daily lives. (Nonsmoking status and low SHS exposure are determined by self-report on the screening questionnaire, salivary cotinine \< 10 ng/ml and THC \< 50 ng/m and exhaled CO2 below 4 ppm)

Exclusion Criteria:

• * Current use of cannabis products, including CBD and edible THC products
• * Regular exposure to secondhand tobacco or cannabis smoke
• * Positive SARS-CoV-2 antibody test
• * Age 18 \< or \> 50
• * Physician diagnosis of asthma, heart disease, hypertension, thyroid disease, diabetes, renal or liver impairment or glaucoma.
• * Unstable psychiatric condition (such as current major depression, history of schizophrenia or bipolar disorder) or current use of more than two psychiatric medications
• * Systolic blood pressure \> 150
• * Diastolic blood pressure \> 100
• * Pregnancy or breastfeeding (by urine hCG and/or history)
• * Alcohol or illicit drug dependence within the past 5 years
• * BMI \> 35 and \< 18
• * Current illicit drug use (by history or urine test)
• * More than 1 pack year smoking history
• * Ever a daily marijuana smoker
• * Smoked anything within the last 2 months
• * Occupational exposure to smoke, dusts OR fumes
• * Concurrent participation in another clinical trial
• * Unable to communicate in English
• * No social security number