Long-term, Substantial Weight Loss and Insulin Regulation of Lipolysis
It is not known how much improvement in insulin regulated lipolysis (the breakdown of triglycerides) occurs following substantial, sustained weight loss. Researchers will test the effects of inflammation and lipolysis regulation in people before and after bariatric surgery (sleeve gastrectomy) to answer these questions.
Conditions:
🦠 Obesity, Morbid
🗓️ Study Start (Actual) 1 August 2019
🗓️ Primary Completion (Estimated) May 2025
✅ Study Completion (Estimated) May 2025
👥 Enrollment (Estimated) 30
🔬 Study Type INTERVENTIONAL
📊 Phase NA
Locations:
📍 Rochester, Minnesota, United States

📋 Eligibility Criteria

Description

    Inclusion Criteria:

    • * BMI 40 - 50 kg/m2.
    • * Mo active physical illness that would interfere with mobility or weight loss after bariatric surgery

    Exclusion Criteria:

    • * Type 1 or Type 2 Diabetes diagnosis or fasting plasma glucose ≥126 mg/dL
    • * Active coronary artery disease
    • * Participation in structured exercise (\>2 times per week for 30 minutes or longer)
    • * Smoking
    • * Medications known to affect adipose tissue metabolism (e.g., beta blockers, corticosteroids)
    • * Renal insufficiency (serum creatinine \> 1.5mg/dl)
    • * Chronic active liver disease (Bilirubin \> 17mmol/L, AST \> 144 IU/L, or ALT\>165IU/L)
    • * Pregnancy or breastfeeding.
Ages Eligible for Study: 18 Years to 65 Years (ADULT, OLDER_ADULT)
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers: No

🗓️ Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

  • First Submitted 7 March 2019
  • First Submitted that Met QC Criteria 8 March 2019
  • First Posted 11 March 2019

Study Record Updates

  • Last Update Submitted that Met QC Criteria 5 June 2024
  • Last Update Posted 6 June 2024
  • Last Verified December 2023