Description
Inclusion Criteria:
- * Clinical diagnosis of cirrhosis based on histology and/or imaging specified in the protocol.
- * Evidence of portal hypertension - must meet at least one of the following criteria:
- * Ascites (present or within past 2 years)
- * Varices (seen by Esophagogastroduodenoscopy or by Ultrasound(US) or cross-sectional imaging)
- * Fibroscan Liver stiffness measurement (LSM) \>25 kilopascals (kPa) (if no other factors present)
- * Magnetic resonance elastography (MRE) LSM \> 5 kPa (if no other factors present)
- * Acoustic radiation force impulse LSM \> 17kpa (if no other factors present)
- * Hepatic vein pressure gradient \> 10 millimetres of mercury (mmHg)
- * Portal hypertensive gastropathy seen on Esophagogastroduodenoscopy
- * Platelet count \< 80/ units per liter (uL)
- * Recanalized umbilical vein (by US or cross-sectional imaging)
- * Access to Wireless Fidelity (Wi-Fi) at home
- * Owns or access to a smartphone, tablet or computer
- * English or Spanish speaking
- * Willing to participate in exercise program
Exclusion Criteria:
- * Overt hepatic encephalopathy (HE) within 6 months, requiring \>28 days total of lactulose
- * Took lactulose for non - HE reasons for \>28 days total in last 6 months
- * Took Rifaximin for \> 28 days total in last 6 months
- * Model for End Stage Liver Disease (MELD) \> 25 (Exception: MELD \> 25 with clinically stable End-Stage Renal Disease (ESRD) for whom the bilirubin is \< 5 g/dL)
- * Barcelona Clinic Liver Cancer (BCLC) \> C Hepatocellular Carcinoma (HCC)
- * Currently taking Sorafenib, Atezolizumab/Bevacizumab, Regorafinib, or Cabozatinib
- * Greater than (\>) 3 paracentesis/month in last 2 months
- * Active Metastatic solid malignancy or acute leukemia within last 3 years
- * Severe cognitive, vision, or hearing impairment (without use of corrective lenses or hearing assist devices) or psychiatric illness precluding study participation
- * Currently participates in Tai-Chi or performs \>150 min/week vigorous physical activity
- * Currently receiving lower body physical and/or occupational therapy
- * Living in an assisted living facility
- * Hemoglobin A1C \> 12 (within past 12 months)
- * Requires a low galactose diet
- * Deemed unsuitable by the study investigator
- Inclusion Criteria for the Caregivers of the participants:
- * Adult \> 18 years of age
- * Informal caregiver of a participant enrolled in LIVE-SMART
- * English speaking
- Exclusion Criteria for the Caregivers of the participants:
- - Non-English speaking
Ages Eligible for Study:
18 Years to N/A (ADULT, OLDER_ADULT)
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers:
No