Inclusion Criteria:

• 1. Patients with history of a WHO Grade II-IV glioma with radiographic evidence of recurrent or progressive tumor
• * Patient must have received prior radiation therapy for initial treatment of glioma
• * Patients with any number of recurrences are allowed as long as the patient has not undergone re-irradiation
• 2. Brain MRI with contrast demonstrates an enhancing tumor ≤ 6 cm in largest diameter within 60 days prior to registration
• 3. History and physical including neurological exam within 30 days prior to registration
• 4. Karnofsky performance status ≥ 60% within 30 days prior to registration
• 5. Age ≥ 22 years old
• 6. Minimum interval since completion of prior radiation treatment is 8 weeks
• * Patients will only receive re-irradiation if pathology from LITT is consistent with recurrent tumor
• 7. Patients must have signed an approved informed consent
• 8. Patients with the potential for pregnancy or impregnating their partner must agree to practice effective contraceptive methods to avoid conception while on study and for 6 months after study completion.
• 9. Female patients of child-bearing potential must have a negative pregnancy test within 28 days prior to study registration.

Exclusion Criteria:

• 1. Patients that are not surgical candidates for stereotactic biopsy or laser ablation
• 2. Patients with impaired cardiac function or clinically significant cardiac diseases, including any of the following:
• * History or presence of serious uncontrolled ventricular or significant arrhythmias.
• * Any of the following within 6 months prior to registration: myocardial infarction, severe/unstable angina, coronary artery bypass graft, congestive heart failure, cerebrovascular accident, transient ischemic attack , pulmonary embolism
• 3. Infratentorial tumor or evidence of leptomeningeal spread
• 4. Inability to undergo a MRI
• 5. Pregnant or breast-feeding women