Level of Physical Activity and Fear Learning
The proposed experimental study will be the first to investigate whether exercise vs. sitting enhances consolidation of extinction learning in adults with high AS and anxiety disorders, and the mechanistic pathways of expectancy, affect, and key stress response markers.
Conditions:
🦠 Generalized Anxiety Disorder 🦠 Social Anxiety Disorder 🦠 Panic Disorder
🗓️ Study Start (Actual) 31 January 2023
🗓️ Primary Completion (Estimated) 14 January 2025
✅ Study Completion (Estimated) 14 January 2025
👥 Enrollment (Estimated) 50
🔬 Study Type INTERVENTIONAL
📊 Phase NA
Locations:
📍 New York, New York, United States

📋 Eligibility Criteria

Description

    Inclusion Criteria:

    • * Males and females ages 18-60
    • * A primary diagnosis of a DSM-5 anxiety disorder (generalized anxiety disorder, panic disorder, social anxiety disorder)
    • * Anxiety Sensitivity Index-3 score of ≥23 (i.e., high anxiety sensitivity)
    • * Able and willing to provide informed consent

    Exclusion Criteria:

    • * Lifetime Bipolar Disorder or psychosis
    • * Past 3 months substance use disorder or eating disorder
    • * Current PTSD (past PTSD \> 6 months prior to screening is allowed)
    • * High risk for exercise according to the Physical Activity Readiness Questionnaire and American College of Sports Medicine guidelines with excluded active medical conditions including heart conditions, lung disease, bone/joint problems, or seizures
    • * Women who are currently pregnant
    • * Acute suicide risk (active suicidal ideation with plan and intent) as indicated by a score of ≥4 on the Columbia Suicide Severity Rating Scale (C-SSRS)
    • * Benzodiazepine use
    • * Current substance abuse or positive urine toxicology screen (recreational use of marijuana is permitted based on clinical assessment on the MINI structured diagnostic interview that it does not meet criteria for cannabis use disorder)
    • * Stable psychiatric medications for at least 4 weeks prior to experimental procedures
Ages Eligible for Study: 18 Years to 60 Years (ADULT)
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers: No

🗓️ Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

  • First Submitted 20 January 2022
  • First Submitted that Met QC Criteria 20 January 2022
  • First Posted 24 January 2022

Study Record Updates

  • Last Update Submitted that Met QC Criteria 22 February 2024
  • Last Update Posted 23 February 2024
  • Last Verified February 2024