NOT_YET_RECRUITING
Investigating the Effects of Social Stress on Brain Imaging
The purpose of this study is to examine whether experiencing a social stressor prior to the collection of neuroimaging measures is associated with differences in brain activation in healthy participants.
Conditions:
🦠 Social Stress
🗓️ Study Start (Actual) December 2023
🗓️ Primary Completion (Estimated) December 2024
✅ Study Completion (Estimated) May 2025
👥 Enrollment (Estimated) 50
🔬 Study Type INTERVENTIONAL
📊 Phase NA
Locations:
📍 Boston, Massachusetts, United States
📍 Cambridge, Massachusetts, United States

📋 Eligibility Criteria

Description

    Inclusion Criteria:

    • * Ability and willingness to provide written informed consent.
    • * Sufficiently fluent in English to participate in the trial.
    • * Between 18-55 years of age (inclusive).
    • * Right-hand dominant.
    • * Current medications are stable for past 30 days (no changes to dose or frequency).
    • * Negative result on pregnancy test (if female).
    • * Negative result on urine drug screening.
    • * No clinically significant mental health disorders (QuickSCID-5).
    • * Liebowitz Social Anxiety Scale (LSAS \<30).

    Exclusion Criteria:

    • * History of bipolar disorder, schizophrenia, psychosis, delusional disorders.
    • * History of eating disorder within past 6 months.
    • * History of any traumatic brain injury.
    • * Currently diagnosed with diabetes mellitus.
    • * Presence of severe medical illness that would prevent completion of study procedures.
    • * Presence of significant neurological illness or cognitive dysfunction (e.g.; seizures, dementia).
    • * History of substance use disorder within past 6 months (other than nicotine and caffeine).
    • * Use of any cannabis-containing products in past 30 days (CBD or THC).
    • * Use of beta-blockers or benzodiazepines in past 2 weeks.
    • * History of claustrophobia.
    • * Contraindications for MRI (e.g.; shrapnel).
    • * Presence of any other medical condition that, in the investigator's opinion, may interfere with the study procedures.
Ages Eligible for Study: 18 Years to 55 Years (ADULT)
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers: Yes

🗓️ Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

  • First Submitted 19 October 2022
  • First Submitted that Met QC Criteria 19 October 2022
  • First Posted 24 October 2022

Study Record Updates

  • Last Update Submitted that Met QC Criteria 26 September 2023
  • Last Update Posted 28 September 2023
  • Last Verified September 2023