Inclusion Criteria:

• PWH:
• * Age ≥18 years, patient receiving care at one of the 3 clinical sites;
• * can identify a support person injector (i.e., family, friend, or partner) who is willing and able to provide injections;
• * has received at least the loading dose of cabotegravir/rilpivirine CAB/RPV (i.e., 600mg/900mg IM) without serious adverse events;
• * is virologically suppressed (HIV RNA \<50 copies/mL);
• * has no history of treatment failure;
• * has no known or suspected resistance to either RPV or CAB;
• * is interested in receiving home-based injections; is approved by their clinical team as a candidate for home-based injections;
• * has the intention to use CAB/RPV for at least 12 months;
• * and is willing and able to give informed consent.
• Treatment Buddy:
• * Age ≥18 years,
• * identified by the PWH,
• * is willing and able to provide monthly or bimonthly LAI-ART injections at the PWH's place of residence, and
• * is willing and able to give informed consent.

Exclusion Criteria:

• PWH:
• * \<18 years of age, not receiving care at one of 3 clinic sites,
• * cannot identify a support person injector,
• * has not received at least the loading dose of CAB/RPV,
• * had serious adverse events with CAB/RPV with the loading dose,
• * is not virologically suppressed,
• * has a history of treatment failure,
• * has a known or suspected resistance to either RPV or CAB,
• * is not interested in receiving home-based injections,
• * is not approved but their clinical team as a candidate for home-based injections;
• * does not have the intention to use CAB/RPV for at least 12 months;
• * and is not willing or unable to give informed consent.
• Treatment Buddy:
• * \<18 years of age,
• * is not willing or unable to provide monthly or bimonthly LAI-ART injections at the PWH's place of residence, and
• * is not willing or unable to give informed consent.