Impact of Respiratory Training in Lymphoma Survivors
High-resistance inspiratory muscle strength training (IMST) is a time-efficient (\~5 minutes/day) form of exercise that employs an affordable, handheld device which impedes inspiratory breathing to train the diaphragm and accessory respiratory muscles and has demonstrated improvements in both cardiovascular health (9 mmHg reduction in systolic blood pressure, 45% improvement in vascular endothelial function) and improve exercise tolerance (12% increase in treadmill exercise time) in generally healthy midlife/older adults. Therefore, this approach may circumvent preventative hurdles to exercise, and augment the effects of exercise for capable survivors.
Conditions:
🦠 Hodgkin Lymphoma 🦠 Non Hodgkin Lymphoma
🗓️ Study Start (Actual) December 2024
🗓️ Primary Completion (Estimated) January 2025
✅ Study Completion (Estimated) January 2026
👥 Enrollment (Estimated) 24
🔬 Study Type INTERVENTIONAL
📊 Phase NA
Locations:
📍 Aurora, Colorado, United States
📍 Aurora, Colorado, United States

📋 Eligibility Criteria

Description

    Inclusion Criteria:

    • * Age 18 - 80
    • * Primary cancer diagnosis of lymphoma
    • * Able and willing to participate in a supervised exercise program at the Anschutz Health and Wellness Center
    • * Provides a signed physician exercise clearance form
    • * SBP \> 120 mmHg
    • * Completion of curative cancer treatment over 12 months prior (individuals on maintenance therapy will be included)
    • * Possession of a smartphone compatible with the IMST training application (available on both Android and Apple).

    Exclusion Criteria:

    • * oSecond active cancer diagnosis
    • * oPlanned active cancer treatment or change in current treatment in the next 6 months
    • * Severe obesity (BMI \> 40 kg/m2) or underweight (BMI \< 18.5 kg/m2)
    • * Unstable weight (\> 3 kg change in body mass in last 3 months)
    • * Significant metabolic disorder (e.g. diabetes type II)
    • * Uncontrolled thyroid disease
    • * Recent changes in hypertensive medication (within last 3 months)
    • * Greater than 100 min of self-reported regular exercise per week
    • * Any medical condition that would impact the safety of, or participation in, an exercise program, including:
    • * Significant pulmonary conditions such as chronic obstructive pulmonary disease, emphysema, or interstitial lung disease
    • * Known cardiovascular disease, significant hypertension (\> 180/120), or a recent cardiac event (within past 6 months)
    • * Orthopedic conditions such as advanced osteoarthritis, mobility-limiting amputations or chronic injuries, or mobility-limiting acute orthopedic injuries
    • * Advanced rheumatoid arthritis or chronic widespread pain conditions such as fibromyalgia
Ages Eligible for Study: 18 Years to 80 Years (ADULT, OLDER_ADULT)
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers: No

🗓️ Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

  • First Submitted 30 June 2023
  • First Submitted that Met QC Criteria 30 June 2023
  • First Posted 10 July 2023

Study Record Updates

  • Last Update Submitted that Met QC Criteria 12 January 2024
  • Last Update Posted 16 January 2024
  • Last Verified January 2024