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Imaging the Pathogenesis of Cerebral Small Vessel Disease
Cerebral small vessel disease (CSVD) can lead to vascular cognitive impairment and dementia (VCID). The hallmark of CSVD is the appearance and progression of white matter hyperintensities (WMH) on MRI. The goal of this study it to recruit and follow individuals at risk for WMH progression and use serial MRI scanning to gain insights into the pathogenesis of CSVD.
Conditions:
🦠 Ischemic Stroke 🦠 Hypertension 🦠 Hyperlipidemias 🦠 Diabetes
🗓️ Study Start (Actual) 8 November 2022
🗓️ Primary Completion (Estimated) 31 March 2027
✅ Study Completion (Estimated) 31 March 2027
👥 Enrollment (Estimated) 50
🔬 Study Type OBSERVATIONAL
📊 Phase N/A
Locations:
📍 Baltimore, Maryland, United States

📋 Eligibility Criteria

Description

    Inclusion Criteria:

    • * Clinical or radiographic evidence of ischemic stroke
    • * One vascular risk factor (hypertension, hyperlipidemia, or diabetes)
    • * Evidence of cerebral small vessel disease on MRI

    Exclusion Criteria:

    • * Inability to complete 3 research MRI scans over 1.25 years
Ages Eligible for Study: 18 Years to N/A (ADULT, OLDER_ADULT)
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers: No

🗓️ Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

  • First Submitted 6 January 2023
  • First Submitted that Met QC Criteria 18 January 2023
  • First Posted 30 January 2023

Study Record Updates

  • Last Update Submitted that Met QC Criteria 6 February 2024
  • Last Update Posted 8 February 2024
  • Last Verified February 2024
I'm interested ...!!