Inclusion Criteria:

• * Biopsy proven soft tissue sarcoma of the extremity, trunk, or head and neck
• * No prior sarcoma-directed therapy
• * Age ≥ 18 years
• * Karnofsky performance status ≥ 60
• * Able to understand and sign an informed consent
• * Life expectancy of greater than 12 weeks
• * Hypofractionated or conventionally fractionated radiotherapy using Intensity Modulated Radiation Therapy (IMRT) are both deemed feasible and safe neoadjuvant treatments, at the treating physician's discretion
• * Operable disease and medically fit for surgery, based on the opinion of the consulting surgeon; surgery within 5-14 days of completion of radiation therapy (RT)
• * Adequate bone marrow function as defined by absolute neutrophil count \> 500/mcL, hemoglobin \> 8 g/dL, platelets \> 50,000/mcL; adequate renal function as defined by creatinine clearance \> 30 mL/min

Exclusion Criteria:

• * Pregnant
• * Unable to undergo imaging or positioning necessary for radiotherapy planning