Inclusion Criteria:

• Inclusion Criteria for Healthy Control Subjects
• 1. Subject has no diagnosed pulmonary conditions
• 2. Subject has not smoked in the previous 5 years.
• 3. Smoking history, if any, is less than or equal to 5 pack-years.
• Inclusion Criteria for Subjects with lung disease
• 1. Subject has a diagnosis of pulmonary dysfunction made by a physician
• 2. No acute worsening of pulmonary function in the past 30 days

Exclusion Criteria:

• 1. Subject is less than 18 years old
• 2. MRI is contraindicated based on responses to MRI screening questionaire
• 3. Subject is pregnant or lactating
• 4. Respiratory illness of a bacterial or viral etiology within 30 days of MRI
• 5. Subject has received an investigational medicinal product (not including 129Xe) within 30 days of MRI
• 6. Subject has any form of known cardiac arrhythmia
• 7. Subject does not fit into 129Xe vest coil used for MRI
• 8. Subject cannot hold his/her breath for 15 seconds
• 9. Subject deemed unlikely to be able to comply with instructions during imaging