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HIIT Effects on Cardiometabolic Health
The primary aim of this randomized clinical trial is to compare the effects of three different HIIT protocols and a control group on cardiometabolic health in young adults with obesity. Participants will be randomly assigned to one of the following three groups, with each having varying work-to-rest ratios: 1) HIIT-A, 2) HIIT-B, 3) HIIT-C, and 4) control group. HIIT-A, HIIT-B, and HIIT-C groups will participate in six sessions of a running based HIIT program over a 2-week training period. Pre-clinical markers of cardiovascular disease, blood lipids and fasting glucose will be measured at the following three time points: baseline, post-intervention, and 2 weeks after the training cessation (i.e., measure for detraining effect). All measurements will be performed three days before the training program and three days after the intervention to avoid the effect of the last training session. Afterwards, the detraining test will be measured 2 weeks post intervention.
Conditions:
🦠 Obesity 🦠 Cardiovascular Diseases 🦠 Metabolic Disease 🦠 High-intensity Interval Training
🗓️ Study Start (Actual) 10 February 2023
🗓️ Primary Completion (Estimated) 10 February 2024
✅ Study Completion (Estimated) 10 December 2024
👥 Enrollment (Estimated) 60
🔬 Study Type INTERVENTIONAL
📊 Phase NA
Locations:
📍 Syracuse, New York, United States

📋 Eligibility Criteria

Description

    Inclusion Criteria:

    • * Young adults with obesity (Age 18 to 25 years old, BMI ≥ 30 kg/m2).

    Exclusion Criteria:

    • * Syndromic obesity; 1) Any clinical symptoms including cognitive delay, 2) abnormalities in body structure(s), 3) organ-specific abnormalities (kidney, liver failure, excessive eating, and/or other signs of hypothalamic dysfunction such as fatigue, weakness and/or lack of interest in activities.
    • * Taking weight loss medication(s)
    • * Currently enrolled (or within previous 6 months) in a weight loss program;
    • * An underlying disease/medications (steroids, second generation psychotropic agents, hormonal contraception, statins, antihypertensive and antidiabetic medications) that could influence carbohydrate or lipid metabolism.
    • * Presence of cardiac pacemaker.
    • * Current or anticipated participation in another research that would interfere with any of the outcomes.
    • * Current or anticipated pregnancy.
Ages Eligible for Study: 18 Years to 25 Years (ADULT)
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers: No

🗓️ Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

  • First Submitted 13 February 2023
  • First Submitted that Met QC Criteria 19 April 2023
  • First Posted 3 May 2023

Study Record Updates

  • Last Update Submitted that Met QC Criteria 19 April 2023
  • Last Update Posted 3 May 2023
  • Last Verified April 2023
I'm interested ...!!