Description
Inclusion Criteria:
- * Age greater than or equal to 18 years old
- * Undergoing medically necessary diagnostic or interventional right cardiovascular catheterization, alone or in combination with a left cardiovascular catheterization
Exclusion Criteria:
- * Cardiovascular instability including ongoing acute myocardial infarction, refractory angina or ischemia, and decompensated congestive heart failure.
- * Women who are pregnant or nursing
- * Unable to undergo magnetic resonance imaging
- * Cerebral aneurysm clip
- * Neural stimulator (e.g. TENS-Unit)
- * Any type of ear implant
- * Ocular foreign body (e.g. metal shavings)
- * Metal shrapnel or bullet.
- * Any implanted device (e.g. insulin pump, drug infusion device), unless it is labeled safe for MRI
- EXCLUSION CRITERIA FOR GADOLINIUM-BASED CONTRAST AGENTS:
- Renal excretory dysfunction, estimated glomerular filtration rate \< 30 mL/min/1.73m2 body surface area according to the Modification of Diet in Renal Disease criteria
- Glomerular filtration rate will be estimated using the CKD-EPI equation:
- eGFR = 141 x (minimum of (S(Cr)/k, 1)\^alpha x (maximum of (S(Cr) /k, 1))\^-1.209 x 0.993\^Age x 1.018 (if female) x 1.159 (if black)
- Where
- S(Cr) = serum creatinine
- alpha = -0.329 for females and -0.411 for males
- k = 0.7 for females and 0.9 for males
- Subjects meeting this exclusion criterion may still be included in the study but may not be exposed to gadolinium-based contrast agents.
- Exclusion criteria for ferumoxytol:
- * Allergy to ferumoxytol or to mannitol excipient
- * Does not wish to be exposed to ferumoxytol
- Exclusion criteria for MRI left heart catheterization:
- -Severe aortic valve stenosis
Ages Eligible for Study:
18 Years to N/A (ADULT, OLDER_ADULT)
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers:
No