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Genetic Markers of Cardiovascular Disease in Epilepsy
Epilepsy is a common condition which affects over 3 million people in the US. Patients with uncontrolled epilepsy have a lifetime risk of sudden unexpected death (SUDEP) of 35%, which is greatest in those under 40 years of age. The exact mechanisms and causes are not understood but can be due to underlying conditions which affect the heart and brain, which may lead to dangerous heart rhythms and death. Some of these conditions which affect heart and brain have an identifiable genetic cause. This study aims to identify known genetic causes of heart rhythm and sudden death related disorders in patients with epilepsy.
Conditions:
🦠 Epilepsy 🦠 Seizures 🦠 Syncope 🦠 Channelopathy 🦠 Cardiomyopathies
🗓️ Study Start (Actual) May 2016
🗓️ Primary Completion (Estimated) December 2028
✅ Study Completion (Estimated) December 2029
👥 Enrollment (Estimated) 600
🔬 Study Type OBSERVATIONAL
📊 Phase N/A
Locations:
📍 Rochester, Minnesota, United States

📋 Eligibility Criteria

Description

    Inclusion Criteria:

    • * Adults ages 18 - 50 with a diagnosis of epilepsy or seizures, or syncope or drowning or cardiac arrest or sudden death or an abnormal ECG suggestive of an arrhythmia
    • * Blood-relatives (Aged 18+) of a patient with a history of epilepsy, seizure, cardiac arrest, sudden death, drowning, syncope or arrhythmia

    Exclusion Criteria:

    • * Those who are unable to provide written consent.
    • * Prisoners (vulnerable population)
    • * Seizures secondary to ischemic events
    • * Traumatic brain injury resulting in seizures
    • * History of cranial surgery
    • * History of brain tumor
Ages Eligible for Study: 18 Years to 50 Years (ADULT)
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers: No

🗓️ Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

  • First Submitted 22 June 2016
  • First Submitted that Met QC Criteria 2 July 2016
  • First Posted 7 July 2016

Study Record Updates

  • Last Update Submitted that Met QC Criteria 1 August 2023
  • Last Update Posted 3 August 2023
  • Last Verified August 2023
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